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\nThe exact cause of atherosclerosis isn't known. However, studies show that atherosclerosis is a slow, complex disease that may start in childhood. It develops faster as you age.
\nAtherosclerosis may start when certain factors damage the inner layers of the arteries. These factors include:
\nPlaque may begin to build up where the arteries are damaged. Over time, plaque hardens and narrows the arteries. Eventually, an area of plaque can rupture (break open).
\nWhen this happens, blood cell fragments called platelets (PLATE-lets) stick to the site of the injury. They may clump together to form blood clots. Clots narrow the arteries even more, limiting the flow of oxygen-rich blood to your body.
\nDepending on which arteries are affected, blood clots can worsen angina (chest pain) or cause a heart attack or stroke.
\nResearchers continue to look for the causes of atherosclerosis. They hope to find answers to questions such as:
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