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Alpha-1 Antitrypsin Deficiency - Signs, Symptoms, and Complications - Signs, Symptoms, and Complications

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The first lung-related symptoms of AAT deficiency may include shortness of breath, less ability to be physically active, and wheezing. Some people may not have any symptoms or complications. AAT deficiency can lead to lung and liver diseases.

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\n Signs and symptoms \n
- Alpha-1 Antitrypsin Deficiency - Signs, Symptoms, and Complications

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Symptoms of AAT deficiency include:

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  • Chronic (ongoing) cough
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  • Feeling tired (fatigue)
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  • Repeat lung infections
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  • Shortness of breath or problems breathing
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  • Wheezing
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These symptoms usually appear in people between 20 and 50 years old. At first, many people who have AAT deficiency are diagnosed with asthma. This is because wheezing also is a symptom of asthma. Also, people who have AAT deficiency respond well to asthma medicines.

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Some people who have AAT deficiency may have liver damage. Signs of liver damage include Jaundice and swelling in your legs. Rarely, AAT deficiency can cause skin problems, such as painful lumps or patches.

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\n Complications \n
- Alpha-1 Antitrypsin Deficiency - Signs, Symptoms, and Complications

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AAT deficiency can lead to:

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  • Asthma
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  • Bronchiectasis
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  • Cirrhosis, a type of liver disease
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  • COPD. Some people who have severe AAT deficiency develop emphysema, a condition that is part of COPD, often when they are only in their 40s or 50s.
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  • Respiratory failure
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  • Vasculitis, which is inflammation in the blood vessels
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Early diagnosis can help you prevent serious complications by avoiding risk factors such as smoking.

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Syndicated Content Details:
Source URL: https://www.nhlbi.nih.gov/subscribe/3514
Source Agency: NIH Heart, Lung and Blood Institute (NHLB)
Captured Date: 2020-03-19 20:59:00.0
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