{"meta":{"status":200,"messages":[],"pagination":{"max":1,"offset":0,"count":1,"total":1,"pageNum":1,"totalPages":1,"sort":null,"currentUrl":"https://api.digitalmedia.hhs.gov/api/v2/resources/media.json?offset=0&max=1&ignoreHiddenMedia=1&format=json&id=18036&newUrlBase=https://www.nhlbi.nih.gov/subscribe/","nextUrl":null,"previousUrl":null}},"results":[{"content":"<body>\n <div class=\"syndicate\"> \n  <div> \n   <div> \n    <div> \n     <h1 autofocus=\"true\"> Sickle Cell Disease - Types - Types </h1> \n     <div> \n      <div> \n       <div> \n        <div> \n         <div> \n          <div> \n           <p><span><span><span>People who have sickle cell disease have abnormal hemoglobin, called hemoglobin S or sickle hemoglobin, in their&nbsp;</span></span></span><span><span>red blood cells</span></span><span><span><span>. Hemoglobin is a protein in red blood cells that carries&nbsp;</span></span></span><span><span><a href=\"#glossary-term-modal-86897\" aria-controls=\"glossary-term-modal-86897\" data-open-modal=\"glossary-term-modal-86897\" data-id=\"86897\"> oxygen <i aria-hidden=\"true\"></i> </a> <span aria-labelledby=\"glossary-term-modal-86897-heading\" aria-describedby=\"glossary-term-modal-86897-description\"> <span> <span> <span> <span>oxygen</span> <button type=\"button\" aria-label=\"Close this window\" data-close-modal> <i></i> </button> </span> <span> <span>(OK-sih-jen):</span><br> <span>A gas that is essential for humans and other animals to live. It is breathed into the lungs from the air. In the lungs, it enters the bloodstream, where red blood cells transport it to cells throughout your body.</span> </span> </span> </span> </span></span></span><span><span><span>&nbsp;throughout the body. People who have sickle cell disease inherit two abnormal hemoglobin&nbsp;</span></span></span><span><span><a href=\"#glossary-term-modal-83383\" aria-controls=\"glossary-term-modal-83383\" data-open-modal=\"glossary-term-modal-83383\" data-id=\"83383\"> genes <i aria-hidden=\"true\"></i> </a> <span aria-labelledby=\"glossary-term-modal-83383-heading\" aria-describedby=\"glossary-term-modal-83383-description\"> <span> <span> <span> <span>gene</span> <button type=\"button\" aria-label=\"Close this window\" data-close-modal> <i></i> </button> </span> <span> <span>(jeen):</span><br> <span>The unit that passes heredity from parents to children. Genes are pieces of DNA and contain information for making a specific protein.</span> </span> </span> </span> </span></span></span><span><span><span>, one from each parent.</span></span></span></p> \n           <p><span><span><span>The types of sickle cell disease include the following:</span></span></span></p> \n           <ul> \n            <li><span><span><span>Hemoglobin S\u03b20 thalassemia</span></span></span></li> \n            <li><span><span><span>Hemoglobin S\u03b2+ thalassemia</span></span></span></li> \n            <li><span><span><span>Hemoglobin SC</span></span></span></li> \n            <li><span><span><span>Hemoglobin SD</span></span></span></li> \n            <li><span><span><span>Hemoglobin SE</span></span></span></li> \n            <li><span><span><span>Hemoglobin SS</span></span></span></li> \n           </ul> \n           <p><span><span><span>In all types of sickle cell disease, at least one of the two abnormal genes causes a person\u2019s body to make hemoglobin S. When a person has two hemoglobin S genes (hemoglobin SS), the disease is called sickle cell anemia. This is the most common and often most severe type of sickle cell disease. Hemoglobin SC disease and hemoglobin S\u03b2 thalassemia are two other common types of sickle cell disease. Hemoglobin SD and hemoglobin SE are much less common.</span></span></span></p> \n          </div> \n         </div> \n        </div> \n       </div> \n      </div> \n     </div> \n    </div> \n   </div> \n  </div> \n </div>\n <script type=\"application/ld+json\">{\"@context\":\"http://schema.org\",\"@type\":\"Article\",\"headline\":\"Sickle Cell Disease - Types\",\"datePublished\":\"2018-28-29T19:28:00Z\",\"description\":\"In all types of sickle cell disease, at least one of the two abnormal genes causes a person\u2019s body to make hemoglobin S. When a person has two hemoglobin S genes (hemoglobin SS), the disease is called sickle cell anemia. This is the most common and often most severe type of sickle cell disease. Hemoglobin SC disease and hemoglobin S? thalassemia are two other common types of sickle cell disease. Hemoglobin SD and hemoglobin SE are much less common.\",\"about\":\"sickle cell anemia, hemoglobin s, sickling disorder due to hemoglobin s\",\"audience\":\"\",\"dateCreated\":\"2018-28-29T19:28:00Z\",\"dateModified\":\"2026-37-09T03:37:16Z\",\"sourceOrganization\":\"National Heart, Lung, and Blood Institute\"}</script>\n</body><div class='syndicate'><span><Strong>Syndicated Content Details:</strong></span><br/><span>Source URL: <a href='https://www.nhlbi.nih.gov/subscribe/80233'>https://www.nhlbi.nih.gov/subscribe/80233</a></span><br/><span>Source Agency: <a href='http://www.nhlbi.nih.gov'>National Heart, Lung, and Blood Institute (NHLBI)</a></span><br/><span>Captured Date: 2018-08-29 19:28:00.0</span><br/></div><iframe src=\"//www.googletagmanager.com/ns.html?id=GTM-KT9TM9&mediaId=18036&mediaType=html&sourceUrl=https%3A%2F%2Fwww.nhlbi.nih.gov%2Fsubscribe%2F80233&userId=-1&sourceId=9&sourceAcronym=NHLBI&campaignId=-1&campaignName=null&languageId=1&isoCode=eng\" height=\"0\" width=\"0\" style=\"display:none;visibility:hidden\"></iframe><noscript><iframe src=\"//www.googletagmanager.com/ns.html?id=GTM-KT9TM9&mediaId=18036&mediaType=html&sourceUrl=https%3A%2F%2Fwww.nhlbi.nih.gov%2Fsubscribe%2F80233&userId=-1&sourceId=9&sourceAcronym=NHLBI&campaignId=-1&campaignName=null&languageId=1&isoCode=eng\" height=\"0\" width=\"0\" style=\"display:none;visibility:hidden\"></iframe></noscript>","description":"In all types of sickle cell disease, at least one of the two abnormal genes causes a person\u2019s body to make hemoglobin S. When a person has two hemoglobin S genes (hemoglobin SS), the disease is called sickle cell anemia. This is the most common and often most severe type of sickle cell disease. Hemoglobin SC disease and hemoglobin S? thalassemia are two other common types of sickle cell disease. Hemoglobin SD and hemoglobin SE are much less common.","id":18036,"mediaType":"Html","name":"Sickle Cell Disease - Types","sourceUrl":"https://www.nhlbi.nih.gov/subscribe/80233"}]}