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\nWhat is fluoride, and where is it found?
\nFluoride is the name given to a group of compounds that are composed of the naturally occurring element fluorine and one or more other elements. Fluorides are present naturally in water and soil at varying levels.
\nIn the 1940s, scientists discovered that people who lived where drinking water supplies had naturally occurring fluoride levels of approximately 1 part fluoride per million parts water or greater (>1.0 ppm) had fewer dental caries (cavities) than people who lived where fluoride levels in drinking water were lower. Many more recent studies have supported this finding (1).
\nIt was subsequently found that fluoride can prevent and even reverse tooth decay by inhibiting bacteria that produce acid in the mouth and by enhancing remineralization, the process through which tooth enamel is \u201crebuilt\u0094 after it begins to decay (1, 2).
\nIn addition to building up in teeth, ingested fluoride accumulates in bones.
\nWhat is water fluoridation?
\nWater fluoridation is the process of adding fluoride to the water supply so the level reaches approximately 0.7 ppm, or 0.7 milligrams of fluoride per liter of water; this is the optimal level for preventing tooth decay (1).
\nWhen did water fluoridation begin in the United States?
\nIn 1945, Grand Rapids, Michigan, adjusted the fluoride content of its water supply to 1.0 ppm and thus became the first city to implement community water fluoridation. By 2008, more than 72 percent of the U.S. population served by public water systems had access to fluoridated water (3).
\nThe Centers for Disease Control and Prevention (CDC) considers fluoridation of water one of the greatest achievements in public health in the 20th century.
\nCan fluoridated water cause cancer?
\nA possible relationship between fluoridated water and cancer risk has been debated for years. The debate resurfaced in 1990 when a study by the National Toxicology Program, part of the National Institute of Environmental Health Sciences, showed an increased number of osteosarcomas (bone tumors) in male rats given water high in fluoride for 2 years (4). However, other studies in humans and in animals have not shown an association between fluoridated water and cancer (5\u20137).
\nIn a February 1991 Public Health Service (PHS) report, the agency said it found no evidence of an association between fluoride and cancer in humans. The report, based on a review of more than 50 human epidemiologic (population) studies produced over the past 40 years, concluded that optimal fluoridation of drinking water \u201cdoes not pose a detectable cancer risk to humans\u201d as evidenced by extensive human epidemiologic data reported to date (5).
\nIn one of the studies reviewed for the PHS report, scientists at NCI evaluated the relationship between the fluoridation of drinking water and the number of deaths due to cancer in the United States during a 36-year period, and the relationship between water fluoridation and number of new cases of cancer during a 15-year period. After examining more than 2.2 million cancer death records and 125,000 cancer case records in counties using fluoridated water, the researchers found no indication of increased cancer risk associated with fluoridated drinking water (6).
\nIn 1993, the Subcommittee on Health Effects of Ingested Fluoride of the National Research Council, part of the National Academy of Sciences, conducted an extensive literature review concerning the association between fluoridated drinking water and increased cancer risk. The review included data from more than 50 human epidemiologic studies and six animal studies. The Subcommittee concluded that none of the data demonstrated an association between fluoridated drinking water and cancer (6). A 1999 report by the CDC supported these findings. The CDC report concluded that studies to date have produced \u201cno credible evidence\u201d of an association between fluoridated drinking water and an increased risk for cancer (2). Subsequent interview studies of patients with osteosarcoma and their parents produced conflicting results, but with none showing clear evidence of a causal relationship between fluoride intake and risk of this tumor.
\nIn 2011, researchers examined the possible relationship between fluoride exposure and osteosarcoma in a new way: they measured fluoride concentration in samples of normal bone that were adjacent to a person\u2019s tumor. Because fluoride naturally accumulates in bone, this method provides a more accurate measure of cumulative fluoride exposure than relying on the memory of study participants or municipal water treatment records. The analysis showed no difference in bone fluoride levels between people with osteosarcoma and people in a control group who had other malignant bone tumors (7).
\nMore recent population-based studies using cancer registry data found no evidence of an association between fluoride in drinking water and the risk of osteosarcoma or Ewing sarcoma (8, 9).
\nWhere can people find additional information on fluoridated water?
\nThe CDC has information at https://www.cdc.gov/fluoridation/index.html on standards for and surveillance of current fluoridated water supplies in the United States.
\nThe Environmental Protection Agency has more information about drinking water and health at https://www.epa.gov/ground-water-and-drinking-water. The information on this page includes details about drinking water quality and safety standards.
\nCenters for Disease Control and Prevention. Public Health Service report on fluoride benefits and risks. JAMA 1991; 266(8):1061\u20131067.
Centers for Disease Control and Prevention. Achievements in public health, 1900\u20131999: fluoridation of drinking water to prevent dental caries. Morbidity and Mortality Weekly Report 1999; 48(41):933\u2013940.
Centers for Disease Control and Prevention (August 2010). 2008 Water Fluoridation Statistics. Retrieved August 10, 2011.
Bucher JR, Hejtmancik MR, Toft JD, et al. Results and conclusions of the National Toxicology Program\u2019s rodent carcinogenicity studies with sodium fluoride. International Journal of Cancer 1991; 48(5):733\u2013737.
[PubMed Abstract]Committee to Coordinate Environmental Health and Related Programs, Ad Hoc Subcommittee on Fluoride (February 1991). Review of Fluoride: Benefits and Risks. Public Health Service, Department of Health and Human Services. Retrieved August 10, 2011, from http://health.gov/environment/ReviewofFluoride.
National Research Council, Subcommittee on Health Effects of Ingested Fluoride. Carcinogenicity of fluoride. In: Health Effects of Ingested Fluoride. Washington, DC: National Academy Press, 1993.
Kim FM, Hayes C, Williams PL, et al. An assessment of bone fluoride and osteosarcoma. Journal of Dental Research 2011; 90(10):1171\u20131176.
[PubMed Abstract]Blakey K, Feltbower RG, Parslow RC, et al. Is fluoride a risk factor for bone cancer? Small area analysis of osteosarcoma and Ewing sarcoma diagnosed among 0-49-year-olds in Great Britain, 1980-2005. International Journal of Epidemiology 2014; 43(1):224-234.
[PubMed Abstract]Archer NP, Napier TS, Villanacci JF. Fluoride exposure in public drinking water and childhood and adolescent osteosarcoma in Texas. Cancer Causes & Control 2016; 27(7):863-868.
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